ANTI-ISCHEMIC PROPERTIES OF QUATERNARY DERIVATIVES OF Β-BLOCKERS

Makarova Yuliya Alexandrovna, Assistant, sub-department of pathology with the course of pathologic physiology, Medical institute, Mordovia State University named after N. P. Ogaryov (Saransk), Yulya-mm@yandex.ru
Belova Lyudmila Alexandrovna, Candidate of medical sciences, associate professor, sub-department of pathology with the course of pathologic physiology, Medical institute, Mordovia State University named after N.P.Ogaryov (Saransk), lyudbelova@yandex.ru
Balashov Vladimir Pavlovich, Doctor of biological sciences, professor, sub-department of embryology, biology and histology, Medical Institute, Mordovia State University named after N. P. Ogaryov (Saransk), bvp63@yandex.ru
Slesarev Vladimir Olegovich, Candidate of medical sciences, doctor of philosophy, professor, sub-department of pathology with the course of pathologic physiology, Medical institute, Mordovia State University named after N.P.Ogaryov (Saransk), slesarevv@mail.ru

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The anti-ishemic activity of two atenolol quarter derivatives LХТ-2-05 and LХТ-К539 has been studied in equitoxical dozes as 1 % of LD50 specified for mice at intra-abdominal injections. The activity of the compositions has been estimated by 3 models: myocardium adrenal micronecrosis in mice, acute occlusive arrhythmia in cats, and by the model of estimating necrosis zones and ischemia in rats with myo-cardial infarct. The compositions are shown to possess cardio-protective properties, and by a number of indices exceed their structural predecessor. The compositions LXT-2-05 are found to possess a higher anti-ishemic and anti-arrhythmic activity in the model of early occlusive arrhythmia and catecholamin myocardium necrosis.

acute myocardium ischemia, anti-ishemic activity, beta-adrenergic blockers.